WHO ARE WE?
Luye Pharma Group, a member of Luye Life Sciences Group, is an international pharmaceutical company with a focus on targeting four therapeutic areas – central nervous system (CNS), oncology, cardiovascular and metabolism, with CNS and oncology at the core. Global R&D, global manufacturing, and the global sale of innovative medications are the company’s three main strategic priorities.
Luye Pharma (Malaysia) Sdn Bhd has been established in Malaysia since 2010 and our products under Nature Wise® Products believes in “Working with Nature for Good Health”.
Our products are mainly Red Yeast Rice, trademark under Lipascor® (XueZhiKang®) and Hypocol® respectively. In late 2015, we launched the Hypotea®, a herbal tea which consist of Gymnema Slyvestre and Green Tea for general health maintenance.
In 2014, one of our products, XueZhiKang® has completed a Phase II study in the USA. The Phase II results were published in the Journal of Clinical Lipidology and the study concludes that XueZhiKang® significantly reduced non High Density Lipoprotein (HDL also known as good cholesterol) and Low Density Lipoprotein (LDL also known as bad cholesterol).
Another trial conducted by the Oslo University Hospital in Norway indicated that consumption of red yeast rice reduced cholesterol levels by 16% and decreased LDL (low density lipoproteins) or bad cholesterol by 24%. However, HDL (high density lipoprotein) or good cholesterol increased by 5%.
Generally, red yeast rice is produced via solid-state fermentation process from premium rice and pure strain red yeast. The difference lies in the strains of red yeast and fermentation methods used as well as the production conditions. To ensure the safety and good quality of the product for consumer consumption, the Ministry of Health (MOH) has set some guidelines to standardise red yeast rice supplements, not to mention all raw materials and finished products have to meet specifications and manufacturers are required to undergo stringent tests to obtain a Certificate of Analysis which is strictly adhered to by our company.
As for our herbal tea, Hypotea®, we are targeting it as a healthy tea drink for those who wish to maintain their general health. It consist of Gymnema Slyvestre to help regulate blood sugar and Green Tea with it high content of anti-oxidant.
OUR GROUP MISSION
With the vision to be a leading global pharmaceutical company, LUYE PHARMA will keep adhering to the road of innovation and internationalization and endeavour to become one of the top 50 global pharmaceutical companies by 2025.
Why choose Red Yeast Rice?
In his book entitled “Natural Remedies for a Healthy Heart”, the author Dr david Heber, an internationally recognised authority in nutrition and disease prevention at the UCLA centre for Human Nutrition noted that “not everyone can achieve appropriate reduction in cholesterol levels through diet alone or even diet combined with exercise and stress reduction”. In such cases, drug intervention may be necessary. Unfortunately, the use of prescriptive drugs in lowering cholesterol is often associated with high cost maintenance and sometimes undesirable long term side effects.
A few decades ago, treating high cholesterol levels and hypertension was expected to eliminate CHD in patients but in recent years, researchers have discovered that cholesterol isn’t just the problem, inflammation is too. Ongoing research shows that multiple interrelated immune mechanisms in the inflammatory process play a role in CHD. Studies conducted have demonstrated that lowering inflammation in patients who had heart attacks in the past, reduces the risk of them getting a second heart attack or a stroke.
According to Deepak Bhatt, M.D., who is chief of cardiology for the VA Boston Healthcare System and associate professor of medicine at Harvard Medical School, cholesterol-lowering medications called statins appear to reduce arterial inflammation but exactly how inflammation plays a role in heart attacks remains a topic of ongoing research. Whilst more clinical trials are ongoing in this aspect, we can reduce our chances of getting CHD by controlling risk factors for inflammation and making the following lifestyle changes.
Add goodness to your diet
Red yeast rice is a food flavouring and colour additive that has been used in Chinese cuisine for centuries. Xuezhikang (XZK) is an extract of red yeast rice that is used for treating heart diseases in China and other countries. It has been approved by the Food and Drug Administration as a dietary supplement and contains naturally occurring statin-like elements.
Clinical studies in patients have shown that XZK decreases the occurrence of new cardiovascular events and has therapeutic effects that include lowering lipid levels and suppressing inflammation. It has also been reported to markedly lower fasting total cholesterol and triglyceride levels. Another study showed that XZK could inhibit vulnerable plaque progression and rupture in mice by suppressing stress-mediated inflammation.
“Not all red yeast rice are the same”
To determine if the study results can be generalised to other preparations that may have variable chemical profiles and contents, samples from various markets were analysed. The results reveals that the total monacolin content in nine samples of red yeast rice varies from 0% to 0.58%. Of the nine samples of red yeast rice in the market, only one has the full complement of 10 monacolins compounds, and citrinin was found at measurable concentrations in all but two samples.
This further cements the fact that red yeast preparations should not be used interchangeably. It certainly necessitates discretion on the part of the consumer when selecting commercially available red yeast rice preparations.
- Shang Q, Liu Z, Chen K, Xu H, Liu J. A systematic review of xuezhikang, an extract from red yeast rice, for coronary heart disease complicated by dyslipidemia. Evidence-based complementary and alternative medicine: eCAM. 2012;2012:636547
- Zhao SP, Liu L, Cheng YC, Shishehbor MH, Liu MH, Peng DQ, et al. Xuezhikang, an extract of cholestin, protects endothelial function through antiinflammatory and lipid-lowering mechanisms in patients with coronary heart disease. Circulation. 2004;110 (8):915–20.
- Jian HB, Hao XY, Deng CQ, Zhou HT, Lin J. The effects of xuezhikang on serum lipid profile, thromboxane A (2) and prostacyclin in patients with hyperlipidemia. Zhonghua Nei Ke Za Zhi 1999; 38:517-9.
- Heber D, Yip L, Ashley JM, Elashoff DA, Elashoff RM, Go VL. Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am J Clin Nutr 1999; 69:231-6.
- Heber D et al. An analysis of nine proprietary Chinese red yeast rice dietary supplements: implications of variability in chemical profile and contents. J Altern Complement Med. 2001;7(2);133-139.